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Pathology category

Immunology

Code

ANCA

Referral code

RHH

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Test information

This assay is useful in the diagnosis and management of patients with suspected pulmonary-renal syndrome or ANCA-associated small vessel vasculitis. There are 2 common staining patterns seen on immunofluorescence: cytoplasmic- ANCA (C-ANCA) and perinuclear-ANCA (p-ANCA). Other atypical patterns are sometimes seen, but may not have any clinical significance.C-ANCA pattern (IIF) directed against Proteinase 3 (PR3 � detected by ELISA) is strongly associated with Wegener�s granulomatosis. . C-ANCA antibody levels may relate to disease activity and will fall to normal with effective treatment. P-ANCA pattern directed against myeloperoxidase (MPO- ELISA) is commonly associated with microscopic polyangiitis (MPA) and other ANCA-associated small vessel vasculitides, but may also be seen in non-vasculitic chronic inflammatory conditions, such as, ulcerative colitis, rheumatoid arthritis and chronic hepatitis. C-ANCA or p-ANCA pattern on IIF not directed against PR3/MPO are less likely to be clinically significant and may not reflect ANCA-related small vessel vasculitides.

Guidelines

Pre-analytical

Reference range

Tube type

Tube type info

SST, Plain or Lithium Heparin

Special requirements

Plasma or Serum

Minimum volume

Assay frequency

Daily

TAT Inpatient (urgent)

TAT Inpatient

TAT GP/Outpatient

up to 7 days. Urgent assay is available.

Referral lab

Immunology Russells Hall Hospital