17- Hydroxy Progesterone

Pathology category

Biochemistry - referred tests

Code

17HP

Referral code

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Test information

Diagnosis of Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency in neonates and children. Premature or stressed infants may have 17a-OHP levels up to 40 nmol/L whereas untreated 21-hydroxylase deficiency levels are usually >100 nmol/L. Assessing hirsute womem with raised serum FAI and DHEAS levels, or as suggested from a urine steroid profile, for possible late-onset CAH. Monitoring response to treatment of CAH children. Blood should be taken before the first morning dose of corticosteroids.

Guidelines

Pre-analytical

Early morning sample and, if neonate, not before 48 hours. Higher levels if premature. Blood sample should be taken before any emergency administration of corticosteroids. Adult female collect during follicular phase.

Reference range

Units: nmol/L, Neonates (>48 hrs): <8.0 ; Tanner Stage 1 male and female: <5.0 ; Adult males 1.2 - 5.0 ; Adult females 0.6 - 4.0 (follicular phase), 1.0 - 6.0 (luteal phase).

Tube type

Tube type info

SST

Special requirements

Serum

Minimum volume

250 uL

Assay frequency

TAT Inpatient (urgent)

TAT Inpatient

4 weeks

TAT GP/Outpatient

4 weeks

Referral lab

Department of Clinical Biochemistry, Queen Elizabeth Hospital, Birmingham